Author: Duran Kala1
1Ishik University, Erbil, Iraq
Abstract: The paper describes pharamacolgical properties of therapeutic plants Matricaria chamomilla,is referred to as chamomile or German chamomile. It is used in folk medicine and in modern medicine as therapeutic plant in the thearapy of upper respiratory infections and various disorders. Chamomile can live in large areas in nature. Every herbal plant has cytotoxic effects. In determination of any possible cytotoxic effects of Matricaria chamomilla, extracts on HeLa CEACAM cells, serial solutions (1/10, 1/50, 1/100, 1/1000, ) of Matricaria chamomilla, extracts were incubated with HeLa CEACAM cells for 24 and 48 h. The cell viability was calculated by the tetrazolium salt 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Matricaria chamomilla, plant extracts showed toxic effect at 1/10 solution, however toxicity of the extracts definitely decreased at 1/50 solution for 24 and 48 hours. Results suggested that the cytotoxic effect of Matricaria chamomilla extracts were concentration dependent but not timedependent in that less cells were viable at 1/10 solution compared to 1/1000 solution. According to results, the plant extract solution of 1/1000 was calculated as an effective dose for future researches
Keywords: Chamomile, Matricaria Chamomilla, HeLa CEACAM, Cytotoxcity, MTT, Cancer
Achterrath-Tuckermann U, K. R., Flaskamp E, Isaac O, Thiemer K. (1980). Pharmacological investigations with compounds of chamomile. V. Investigations on the spasmolytic effect of compounds of chamomile and Kamillosan on the isolated guinea pig ileum. Planta Medica, 39, 38-50.
Ain Raala*, H. K., Anne Oravb, Elmar Araka, Tiiu Kailasb, and Mati Müüriseppb. (2011). Content and composition of essential oils in some Asteraceae species. Proceedings of the Estonian Academy of Sciences, 60(1), 55-63. doi: doi: 10.3176/proc.2011.1.06
Berry, M. (1995). Herbal products. Part 6. Chamomiles. . Pharmaceutical Journal, 254, 191-193.
Buryakova, I. V., Kurilova, A. I., Badytchik, L. I., andZamarenov, N. A. (2007).
Crevin JK, P. J. (1990). Herbal medicine past and present. USA: Duke University Press.
Davis PH. (1965-1985). Flora of Turkey and East Aegean Islands. Edinburgh: Edinburgh University Press.
Forster HB, N. H., Lutz S. . (1980). Antispasmodic effects of some medicinal plants. Planta Medica, 40, 390-319.
Gardiner, G. (1999). Chamomile (Matricaria recutita, Anthemis nobilis). from The Longwood Herbal Task Force,The Center for Holistic Pediatric Education and Research
Isaac, O. (1979). Pharmacological investigations with compounds of camomile, I. On the pharmacology of – (-)alpha-bisabolol and bisabolol oxides. Planta Med., 35, 118-124.
Issac O. (1989). Recent progress in chamomile research- medicines of plant origin in modern therapy. Czecho-Slovakia: Prague press.
Ivens GM. (1979). Stinking mayweed. N Z J Agric, 21(3), 138.
Jackson, T. (July, 2001). Medical Attributes of Matricaria chamomilla – Chamomile
Kedzia, B. (1991). Antimicroorganism`s activity of Oil Cammomillae and its components. Herba Polonica, 37, 29-38.
Koch C, R. J., Schneele J, Schnitzler P. . (2008). Inhibitory effect of essential oils against herpes simplex virus type 2. Phytomedicine, 15 (1-2), 71-78.
Krishna Murti, M. A. P., Vipul Gajera and Jinal Solanki,. (2012). Pharmacological properties of Matricaria recutita: A Review. Pharmacologia, 3(8), 348-351.
Lim, T. (2014). Matricaria chamomilla. Edible Medicinal And Non-Medicinal Plants. . Springer.
Ahmet Maranki. (2008). Kozmik bilgiler ışığında Şifalı Bitkiler: Mozaik yayınları.
Mericli AH. (1990). The lipophilic compounds of a Turkish Matricaria chamomilla variety with no chamazuline in the volatile oil. . Int J Crude Drug Res. , 28(145), 7.
Mosmann T. (1983). Rapid colorimatric assay for cellular growth andsurvival: Application to proliferation and cytotoxicity assays. J.Immunol. Methods, , 65, 55-63.
Nogueira JC, D. M. F., Lima EO. . (2008). In vitro antimicrobial activity of plants in Acute Otitis Externa. Braz J Otorhinolaryngol, 74(1), 118-124.
Ompal Singh, Z. K., 1 Neelam Misra, and Manoj Kumar Srivastava. (2011). Chamomile (Matricaria chamomilla L.): An overview. Pharmacogn Rev. , 5(9), 82–95.
Pamukov D, A. C. (1986). Natural pharmacy (in Slova). (1st ed ed.). Bratislava: Priroda.
Renuka, C. (Ed.). (1992). Rattans of the Western Ghats: A Taxonomic Manual. .
Royer, F. a. R. D. (1999). Weeds of the Northern US and Canada. (Germplasm Resources Information Network – (GRIN) 2004). Retrieved USDA, ARS, National Genetic Resources Program., from University of Alberta Press
Sadr Lahijani MS, R. K. H., Heady R, Yazdani D. . (2006). The effect of German chamomile (Marticaria recutita L.) extract and tea tree (Melaleuca alternifolia L.) oil used as irrigants on removal of smear layer.a scanning electron microscopy study. int Endod J, 39(3), 190-195.
International Journal of Social Sciences & Educational Studies
ISSN 2409-1294 (Print), June 2014, Vol.1, No.4